Constitutive regulation of the glutamate/aspartate transporter EAAT1 by Calcium-Calmodulin-Dependent Protein Kinase II
نویسندگان
چکیده
منابع مشابه
Calcium/calmodulin-dependent protein kinase II.
There is a great deal known about the in vitro properties of CaM kinase II, both in terms of its substrate specificity and its regulation by calmodulin and autophosphorylation. Much of this characterization is based on experiments performed with the rat brain isozyme of CaM kinase II, although in the aspects examined to date isozymes of the kinase from other tissues appear to behave in a broadl...
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The search for “memory molecules” and why CaMKII is an appealing candidate Since the time neuroscientists first recognized that biochemical events inside neurons could influence the function of the brain, there have been people looking for “memory molecules.” This elusive ion, small molecule, protein, or nucleic acid would be the keystone on which memory was built; understanding the memory mole...
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Thrombin-induced endothelial cell barrier dysfunction is tightly linked to Ca(2+)-dependent cytoskeletal protein reorganization. In this study, we found that thrombin increased Ca(2+)/calmodulin-dependent protein kinase II (CaM kinase II) activities in a Ca(2+)- and time-dependent manner in bovine pulmonary endothelium with maximal activity at 5 min. Pretreatment with KN-93, a specific CaM kina...
متن کاملRegulation of calcium/calmodulin-dependent protein kinase II activation by intramolecular and intermolecular interactions.
As its name implies, calcium/calmodulin-dependent protein kinase II (CaMKII) is calcium dependent. In its basal state, the activity of CaMKII is extremely low. Regulation of intracellular calcium levels allows the neuron to link activity with phosphorylation by CaMKII. This review will briefly summarize our current understanding of the intramolecular mechanisms of activity regulation and their ...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2017
ISSN: 0022-3042
DOI: 10.1111/jnc.13913